Distinct immune profiles in children of high versus low socioeconomic status in Makassar, Indonesia
Author:
Dorst Marloes van1, Stam Koen1, Amaruddin Aldian Irma1, König Marion1, Hamid Firdaus2, Sartono Erliyani1, Wahyuni Sitti2, Jochems Simon P.1, Yazdanbakhsh Maria1
Affiliation:
1. Leiden University Center for Infectious Diseases, Leiden University Medical Center 2. Hasanuddin University
Abstract
Abstract
BACKGROUND
Vaccinations against infectious diseases save millions of lives, however reduced vaccine responses have been observed in low-income settings. Therefore, understanding differences in immune profiles of populations with high or low socioeconomic status (SES) is of importance for optimizing vaccine efficacy.
AIM
Examining the immune profile of children of high versus low SES in the city of Makassar, Indonesia.
METHODS
Using mass cytometry, we profiled immune cells in finger-prick blood samples of children attending high and low SES schools in Makassar, Indonesia.
RESULTS
Distinct immune profiles were found in children from low versus high SES. While increased frequencies of B cells, CD161+ T helper 2 cells and CTLA-4+ Tregs and HLA-DRdimCD163+ monocytes were seen in low SES children, elevated TCRgd T cells and a trend towards expansion of T helper 1 cells were observed in the high SES group.
CONCLUSION
Socioeconomic status appears to have a significant impact on the immune system of children living in the same city. Such differences might contribute to poor vaccine responsiveness that has been reported in low income settings.
Publisher
Research Square Platform LLC
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