Abstract
OBJECTIVES
Toll-like receptors (TLRs) are transmembrane proteins primarily involved in the immune response, mediating the pathophysiological process of cognitive impairment through pathways. Despite an abundance of literature elucidating the role of TLRs in cognitive dysfunction, bibliometric analyses of this topic are notably scarce.
METHODS
We conducted a bibliometric analysis of publications spanning from 2002 to 2023, retrieved from the widely utilized Web of Science Core Collection, employing tools such as R language, CiteSpace software, and the online bibliometric platform (https://bibliometric.com/) for a comprehensive visual analysis. Data analysis was performed using GraphPad Prism and IBM SPSS.
RESULTS
Our findings revealed a total of 502 articles published over the past 11 years. Notably, China contributed significantly, accounting for 39.84% (n = 200) of the publications, underscoring its prominence in this field. The Journal of Brain Behavior and Immunity emerged as the leading journal in terms of article contributions, with 40 publications (7.07%). Author influence, measured by the H-index, highlighted Baluchnejadmojarad, Tourandokht, and Roghani, Mehrdad, as the two most influential authors, each with an H-index of 9. The co-occurrence analysis of keywords revealed that terms such as "activation", "toll-like receptors", and "inflammation" were consistently prevalent in the literature.
CONCLUSION
This visualized bibliometric analysis demonstrated the progress in research related to TLRs in cognitive dysfunction, with a gradual increase in literature volume over the past 11 years. Researchers can derive valuable insights into research trends, frontiers, and influential authors from our study, aiding them in shaping their future research endeavors in this field.