Design of a liposome with the property to induce CD16 on cervical cancer cells with a purified spermidine-cholesterol

Author:

Weiss-Steider Benny1ORCID,Marcelin-Jiménez Gabriel2ORCID,Soto-Vazquez Ramón1,Ramírez Adelfo N. Reyes1ORCID,Rangel-Corona Rosalva1ORCID,Vargas-Angeles Carlos Adrian1,Corona-Ortega María Teresa1ORCID

Affiliation:

1. UNAM

2. Pharmacometrica

Abstract

Abstract Purpose Use of a purified cationic lipid for fabricate liposomes capable of inducing the appearance of CD16 receptors on the membranes of cervical carcinoma cells.Methods Chemical synthesis of purified spermidine-cholesterol; liposome fabrication; UPLC-MS analysis; Cell culture; Flow cytometry.Results The construction of a liposomal system with a highly purified spermidine-cholesterol with CD16 inducing capacity on cervical cancer cells.Conclusion We were able to synthetize a highly purified spermidine-cholesterol to fabricate a liposomal system capable to induce CD16 on cervical cancer cells.

Funder

Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

Publisher

Research Square Platform LLC

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