Outcomes of ovarian-sparing surgery in children with ovarian neoplasm: A meta-analysis and meta-regression

Abstract

Abstract Objectives. Ovarian-sparing surgery (OSS) is increasingly used to treat various ovarian neoplasms (ON) in children. The feasibility and prognosis of OSS on ON are still being explored. The aim of this research was to demonstrate the clinical results of implementing OSS in children diagnosed with ON. Methods. A thorough search was conducted on PubMed, Cochrane Library, and Embase databases to identify relevant articles. The study calculated the recurrence rate, incidence of benign cases and OSS, along with a 95% confidence interval (CI). Results. The study included a total of 14 relevant studies involving 1577 patients. The recurrence rate of ON was 2.0% (95% CI: 1.0%-3.1%), the benign rate was 85.5% (95% CI: 81.5%-89.4%), and the rate of OSS was 60.0% (95% CI: 54.3%-65.6%), the rate of OSS in benign tumors was 497.1% (95% CI: 95.4%-98.8%). As for the distribution of ON: 647 cases (41.2%) of non-neoplastic cysts, 580 cases (36.9%) of germ cell tumors, 279 cases (17.7%) of epithelial tumors, and 61 cases (3.9%) of Sex cord-stromal tumor. Conclusions. The results of this meta-analysis suggest that the majority of ON in children is benign and has a meager tumor recurrence rate. TSS should be provided to children with benign lesions to ensure future hormone secretion and reproductive function.