Gender-related association of osteoporosis and bone mineral density with body fat distribution in the general US population: a case control study

Abstract

Abstract Background: There have been few population-based studies investigated the association between fat distribution and osteoporosis and the bone mineral density (BMD). Methods: Our survey was based on the data from 2017-2018 National Health and Nutrition Examination Survey (NHANES). A total body dual energy X-ray absorptiometry (DXA) scan was conducted to assess the body composition. Participants were asked whether they had previously received a physician diagnosis of osteoporosis through the survey. To assess the effects of body mass index (BMI) and android: gynoid ratio (AGR) on osteoporosis in male and female, we performed the multivariate logistic regression analysis. Results: A total of 336 male and 329 female subjects participated in the study. In male, BMI was positively correlated with BMD of lumbar spine and lower limbs. And there was no significant interaction between AGR and BMD. There were positive correlations between both BMI and AGR and the BMD of lower limbs in female. And only BMI was positively correlated with lumbar spine BMD. Conclusions: BMI was negatively associated with the risk of osteoporosis in male. For female, such protect was caused by AGR.