Reversal of epigenetic age and improvement of body composition in consumers of wine enriched with Resveratrol.

Abstract

Abstract Biological aging (BA) is a universal process that involves the deterioration of vital functions. One of the root causes of BA is epigenetic DNA hypermethylation. The latter defines epigenetic age (EA), being the most important risk factor for chronic non-communicable diseases, so its modulation is an exciting emerging field of science. Although there are numerous investigations on the mechanisms of aging, today there are few studies that measure EA in humans after an intervention. The objective of this research was to evaluate the EA and the body composition after the consumption of wine enriched with Resveratrol. The results showed a decrease in EA after three and a half months of the study intervention (p < 0.01). We also demonstrated significant improvements in body composition with a 1.6 kg decrease in fat mass, (p < 0.0004); and an increase in muscle mass of 300 g (p < 0.019). To our knowledge, it is the first time that a highly significant reduction of EA has been demonstrated in consumers of wine enriched with Resveratrol combined with a healthy remodeling of body composition. These findings could be relevant to maintaining health, increasing life expectancy, and preventing the damages caused by aging.