Affiliation:
1. Departemnt of Emergency Medicine , Shenzhen Second People’s Hospital / the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen
2. Department of Nephrology, Shenzhen Second People’s Hospital / the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen
Abstract
Abstract
Objective
There is still little evidence on the relationship between blood urea nitrogen to albumin (BUN/ALB) ratio and 3-month outcomes in patients with acute ischemic stroke (AIS). Therefore, this study aimed to explore the association between BUN/ALB ratio and 3-month poor outcomes in AIS patients.
Methods
A retrospective study of 1868 AIS participants was conducted in a Korean hospital from January 2010 to December 2016. Binary logistic regression, smooth curve fitting, and subgroup sensitivity analysis were used to analyze the association between BUN/ALB ratio and 3-month poor outcomes.
Results
After adjusting covariates, the results of the binary logistic regression model suggested that the relationship between the BUN/ALB ratio and the risk of 3-month poor outcomes for AIS patients was not statistically significant in model II. However, there was a special nonlinear relationship between them, and the inflection point of the BUN/ALB ratio was 0.326. On the left side of the inflection point, 0.1-unit increase in the BUN/ALB ratio reduces the risk of 3-month poor outcomes by 42% (OR = 0.58, 95% CI: 0.40 to 0.83, P = 0.0033). On the right side of the inflection point, the relationship is not statistically significant.
Conclusion
There is a nonlinear relationship with saturation effect between BUNALB ratio and 3-month poor outcomes in AIS patients. Maintaining a patient's BUN/ALB ratio of around 0.326 can reduce the risk of 3-month poor outcome in AIS patients.
Publisher
Research Square Platform LLC