Abstract
Summarize and analyze the clinical characteristics of early esophageal cancer mainly manifested by leukoplakia.The clinical features between complete leukoplakia type and mixed type of early esophageal cancer have some differences as well as commonalities in the meantime. The lesions have clear borders, irregular patterns, and uneven thickness of leukoplakia, which occur mostly in the background of the mottled esophagus, and the location of the lesions is predominantly in the middle and lower parts of the esophagus. Pathologic findings of complete leukoplakia-type lesions were predominantly low-grade intraepithelial neoplasia and high-grade intraepithelial neoplasia (M1), and mixed lesions were predominantly high-grade intraepithelial neoplasia (M1) and intra-intrinsic invasive squamous cell carcinoma (M2). Complete leukoplakia-type lesions are relatively young and the lesion area is smaller than that of mixed lesions, the lesion morphology is mostly IIa, the surface IPCL is mostly invisible under NBI magnification, and the Lugol's iodine staining is lightly stained or unstained. Mixed lesions tend to occur in older patients, the lesion area is larger than the other, the lesion morphology tends to show IIa + IIb, NBI magnification of the surface IPCL is more likely to be visible, and Lugol's iodine staining tends to be unstained.