Comparison of Pulmonary Computed Tomography Images and Quantitative Parameters in Patients with Different Degrees of Chronic Obstructive Pulmonary Disease

Abstract

Abstract to investigate the computed tomography (CT) pulmonary imaging characteristics and quantitative parameters of patients with various degrees of chronic obstructive pulmonary disease (COPD), 120 patients with stable COPD were classified into grade I of mild (n = 24), grade II of moderate (n = 58), grade III of severe (n = 30) and grade IV of very severe (n = 8) according to the 2011 Global Initiative for COPD (GOLD) strategy. The forced expiratory volume in one second (FEV1), maximum forced vital capacity (FVC), FEV1/FVC, and FEV1/predicted value were measured. Routine blood tests were performed with an automatic hematology analyzer. The results showed a remarkabledifference in FVC between grade III and IV preoperatively and postoperatively (P < 0.05). The FEV1 values of grades II, III, and IV were drastically different postoperatively compared with those preoperatively (P < 0.05). Pearson correlation analysis(PCA) showed that FEV6 was positively correlated with FVC, R = 0.961 before treatment, R = 0.947 after treatment (P < 0.05). No great differences were discoveredin white blood cell count (WBC), platelet count (PLT), C-reactive protein (CRP), or neutrophil count percentage (NEU)% among patients with the four grades (P < 0.05). Quantitative CT can evaluate the severity of emphysema in COPD patients, and the pulmonary function of patients wasdrastically improved after treatment.