Affiliation:
1. ICMR-National Institute of Occupational Health
2. U.N.Mehta Institute of Cardiology and research centre
3. GMERS medical college
Abstract
Abstract
Background & Objective: Exposure to air pollutant is a threat to human health. Present study explored the association between air pollutant exposure from all potential sources using micro-environment modelling and the risk of cardiovascular illness.
Methods: Present hospital based study recruited consecutive consenting patients, requiring coronary artery calcification (CAC) evaluation, after obtaining institutional human ethics approval. Fifty participants each with CAC scores <100, 100–399 and ≥400, categorized as low, intermediate and high risk respectively were recruited. Details on basic demographics, exposure to the air pollutants from individual microenvironments viz. indoors, workplace and outdoors were collected by interview. The cumulative exposure risk hours, from individual microenvironments and total exposure was estimated using mathematical modelling. Additionally cumulative PM2.5 exposure was estimated for a fraction of the participants. The association between exposure to air pollutants and risk for the coronary artery disease was evaluated with standard statistics.
Observations: Increasing age and male sex were significantly associated with CAC scores. Air pollutant exposure at outdoors and workplace were independently (p < 0.05) associated with higher CAC risk. Cumulative PM2.5 exposure residential locations, exhibited a trend of association (p > 0.05) with high risk CAC group
Conclusion: Exposure to air pollutant from workplace and outdoors were significantly associated with higher risk for coronary artery diseases. Age and male sex were independently and significantly associated with higher risk for coronary artery diseases. Current study reinforce the detrimental cardiovascular effects of air pollutant exposure independently using micro-environmental modelling and quantitative PM2.5 estimation.
Publisher
Research Square Platform LLC
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