Plasma metabolomics signatures of developmental dysplasia of the hip in Tibet plateau

Author:

Guo Ye1,li Xiaogang1ORCID,yang De2,Yedron Nyima2,Chen Tao3,Li Jianchu1,Lei Yanming4,Li Ping4,Ji Jiamei1,Shi Li2,Cho Ten2,Yang Xiao1

Affiliation:

1. Peking Union Medical College Hospital

2. People's Hospital of Tibet Autonomous Region

3. Beijing jishuitan Hospital

4. People‘s Hospital of Tibet Autonomous Region

Abstract

Abstract Background: Developmental dysplasia of the hip (DDH) is a common childhood health complaint, whose etiology is multifactorial. The incidence of DDH is variable and higher in Tibet plateau. Here, we collected plasma samples and studied the metabolomics signatures of DDH. Methods: Fifty babies were enrolled: 25 with DDH and 25 age-matched non-DDH healthy controls(HC group). We collected plasma samples, laboratory parameters and conducted untargeted metabolomics profiling. Results: There are many differential metabolites among patients with DDH, including 4-β-hydroxymethyl-4-α-methyl-5-α-cholest-7-en-3-beta-ol, β-cryptoxanthin, α-tocopherol, taurocholic acid, glycocholic acid, 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate, arabinosylhypoxanthine, leucyl-hydroxyproline, hypoxanthine. The main differential metabolic pathways focused on primary bile acid biosynthesis, arginine and proline metabolism, phenylalanine metabolism, histidine metabolism, purine metabolism. Conclusions: To our knowledge, this is the first report of metabolomics profile in babies with DHH. By combining the α-tocopherol and taurocholic acid, we could achieve the differential diagnosis of DDH.

Publisher

Research Square Platform LLC

Reference22 articles.

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3. Parth Lodhia, Sarkhell Radha, António Pedro Robalo Correia, Benjamin G Domb, Luis Perez-Carro, Oliver Marín-Peña, Damian R Griffin;Lall C;J Hip Preserv Surg,2020

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5. Munkhtulga Ulziibat B, Munkhuu R, Schmid T, Baumann. Stefan Essig J Child Orthop. 2020;14(4):273–80.

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