Abstract
Background
Middle-aged and older persons are frequently afflicted with osteoporosis and atherosclerosis; however, new evidence indicates a deeper relationship that goes beyond the normal aging process. One new inflammatory measure that has developed for evaluating the risk of cardiovascular disease is the uric acid to high density lipoprotein ratio (UHR).However, research on the relationship between UHR and the risk of developing osteoporosis is still awaiting.
Methods
Between 2011 and 2018, we gathered UHR and bone mineral density (BMD) data from 10,983 individuals in the National Health and Nutrition Examination Survey (NHANES). We employed multivariate linear regression to investigate the relationship between BMD and UHR. Smoothing curves were utilized to deal with nonlinearity. To investigate nonlinear relationships further, we employed a two-part linear regression model. Threshold effects were evaluated using both components of the linear regression model. We also conducted subgroup analyses to ensure the stability of the findings.
Results
In all three models, we found a negative correlation between UHR and lumbar BMD. there was an L-curve correlation between UHR and lumbar BMD, with a critical inflection point of 2.97. the fully adjusted model showed a decrease in lumbar BMD of 0.03 g/cm2 for those in the fourth quartile compared with the lowest quartile. the correlation was consistent across most subgroups, except in the subgroups with a body mass index less than 25 and age greater than 50 and those with diabetes.
Conclusions
According to this study, there appears to be a negative relationship between BMD and NHHR among US adults. More study is needed to determine the precise physiological pathways by which UHR contributes to the development of osteoporosis.