An evaluation of collagen peptide for transdermal delivery using Strat-M ® membrane and excised mouse skin

Abstract

Abstract In the field of medicine and cosmetics, transdermal experiments commonly used to evaluate the transdermal absorption of topical formulations. In this study, we applied Strat-M® membrane to study the in vitro transdermal properties of collagen peptide with different average molecular weight, and compared them with the transdermal absorption through excised mouse skin in vitro. The results showed that the transdermal rate of collagen peptide through Strat-M® and excised mouse skin increased linearly with time, and the different concentrations of collagen peptide solutions affected the final cumulative transmission. The cumulative transmission per unit area and transdermal rate of CP500 were both the highest among the four CPs. The cumulative transmission per unit area of collagen peptides through Strat-M® has a good correlation with that through excised mouse skin, R2 > 0.98. Strat-M® can replace the excised mouse skin in vitro to carry out the transdermal experiment of collagen peptide. Our results can be used to guide formulators in selecting vehicles in early development in the pharmaceutical, personal care and cosmetic industries.