Abstract
Introduction: Epilepsy is a neurological syndrome, caused by an excess of neuronal discharges due to various etiologies with varying degrees of success in treatment. Currently, a part of the population is pharmacoresistant to the traditional treatment, justifying the search for additional options. One of these alternatives is the cannabidiol - a non-psychoactive component of Cannabis Sativa, with an already tried efficacy, but still needing more studies to quantify this efficacy Objectives: Gather and analyze efficacy findings of the use of cannabidiol in pharmacoresistant epilepsy. Methodology: This literature systematic review was made following the PRISMA protocol guidelines. The Google Scholar, Scielo, and PubMed/MEDLINE databases were included. Using the descriptors "Cannabidiol," "Epilepsy," and "Drug Resistant Epilepsy.". This research was registered in the Prospero platform with the identification: CRD42024479643. Results: 1448 results were found in the PubMed, Virtual Health Library, and Google Scholar databases. 06 studies met the criteria for full-text evaluation and eligibility. Compiled analysis showed that the total number of seizures in patients who received cannabidiol demonstrated a reduction of 41.0875% compared to patients in placebo groups who had an average percentage reduction of 18.1%, a 127% higher response for patients who received the intervention. Conclusion: Given these results, it is possible to conclude that the therapeutic response of cannabidiol is worthy of consideration in new protocols and of being added to public healthcare systems for its antiepileptic potential; however, the high efficacy rate of the placebo group suggests that other methods of data collection analysis may be employed