The Dynamic Effects on Bone Mass of Chemotherapy and Surgery in Lung Cancer Patients

Abstract

Abstract Background The aim of this study was to evaluate the dynamic effects on bone mass of chemotherapy and surgery in lung cancer patients by computed tomography (CT). Methods This was a retrospective study, 147 patients with lung cancer from June to December 2021 in our hospital were finally selected. Data consisted of cycle of chemotherapy and surgery. CT scans before chemotherapy and cycle 1-6 after chemotherapy were performed.The CT values of the T11-L1 vertebral body were recorded and compared. Results The mean CT values of T11-L1 vertebral body in cycle 1, 5and 6 were lower than that in pre-chemotherapy (P=0.007＜0.05，P=0.038＜0.05，P=0.048＜0.05). There was no significant difference among the rest groups (all P＞0.05）. The CT value of T11 was higher than those of L1 in pre-chemotherapy and cycle 1, 2 after chemotherapy (P＜0.001，P=0.042< 0.05，P=0.015< 0.05). There was no statistically significant difference in CT values among the T11,T12 and L1 in cycle 3, 4, 5 and 6 (all P＞0.05). There was no statistical significant difference in the mean CT values of the T11-L1 vertebral body between operation group and non-operation group in pre-chemotherapy and same cycle after chemotherapy (all P＞0.05). Conclusions Osteodeficiency exacerbated by ongoing chemotherapy and unaffected by operation in lung cancer patients indicates the need for the development of antiosteoporosis treatment and osteoporosis prophylaxis for lung cancer patients.