Affiliation:
1. University of Alabama
2. MetroHealth Medical Center
3. Summa Health System
Abstract
Abstract
Although nocturnal hypoxemia has been linked to obesity, the relationship between spirometry parameters and nocturnal oxygen saturation (SpO2) has not been well studied in subjects with obesity.
This a retrospective cross-sectional chart review of adult patients with obesity, who had PFT (pulmonary function tests) and diagnostic polysomnogram within 6 months between 2017-2019.
A total of 227 patients were included in the analysis, of which 69% were females and 43.8% were African Americans. In the absence of obstruction on spirometry, FEV1 (forced expiratory volume in first second) and FVC (forced vital capacity) were associated with lower mean nocturnal SpO2. Non-specific ventilatory defect on PFTs was associated with increased odds of having a mean nocturnal SpO2 <92% compared to normal spirometry, and lung volumes (OR:2.15,95%CI:1.02-4.5,p=0.042) with adjustment for age, sex, BMI (body mass index).
Non-specific PFT pattern should prompt screening for sleep symptoms and considering a polysomnogram in subjects with obesity.
Publisher
Research Square Platform LLC
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