Affiliation:
1. The First Clinical College of Zhejiang Chinese Medical University, The First Affiliated Hospital of Zhejiang Chinese Medical University
2. The Second Affiliated Hospital of Zhejiang Chinese Medicine University
Abstract
AbstractIntroductionPeople with hemophilia risk osteoporosis more than healthy people, which may be related to specific factors.MethodsThis case-control study included 53 patients with severe hemophilia type A and 49 healthy participants. Dual-energy X-ray absorptiometry was used to determine bone mineral density (BMD). Collected Information on age, body mass index (BMI), number of deformed joints, Functional Independence Score in Hemophilia (FISH), bone turnover markers, antibodies, treatment modalities. To identify independent risk factors for osteoporosis.ResultsThe BMD of the femoral neck (0.80g/cm2vs.0.97 g/cm2), Ward’s triangle (0.62 g/cm2vs.0.83 g/cm2), tuberosity (0.63 g/cm2vs.0.80 g/cm2) and hip (0.80g/cm2vs.0.98 g/ cm2) in the case group were significantly lower than those in the control group, all of which were P < 0.001. However, there was no significant difference in the overall BMD of lumbar spine(L1-L4) (1.07g / cm2vs. 1.11g / cm2). The incidence of osteoporosis in the case group was 41.51%. BMI and FISH score were considered as independent risk factors for BMD decrease.ConclusionThe BMD of patients with severe hemophilia A is much lower than that of healthy population, and this difference is mainly reflected in the hip. The clear influencing factors were low BMI and functional independence decrease. Osteoclast was active while osteoblast activity was not enhanced synchronously, which may be the pathological mechanism of BMD decrease.
Publisher
Research Square Platform LLC
Reference32 articles.
1. Haemophilia;Berntorp E;Nat reviews Disease primers,2021
2. Osteoporosis in men: a review;Adler RA;Bone Res,2014
3. Osteoporosis in haemophilia - an underestimated comorbidity?;Wallny TA;Haemophilia: the official journal of the World Federation of Hemophilia,2007
4. Osteoporosis management and falls prevention in patients with haemophilia: Review of haemophilia guidelines;Petkovic MJ;Haemophilia: the official journal of the World Federation of Hemophilia,2022
5. Osteoporosis in men: an Endocrine Society clinical practice guideline;Watts NB;J Clin Endocrinol Metab,2012