Increased free water in the nucleus basalis of Meynert is associated with worse olfaction in Parkinson’s disease-Reference-Cited by-同舟云学术

Increased free water in the nucleus basalis of Meynert is associated with worse olfaction in Parkinson’s disease

Published:2024-03-05 Issue: Volume: Page:
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Author:

Wang Chao¹^ORCID,Wang Shuyue¹,Zhou Cheng²,Wu Chengqin³,Zhang Minming²^ORCID,Huang Peiyu¹

Affiliation:

1. The Second Affiliated Hospital, Zhejiang University School of Medicine

2. the Second Affiliated Hospital of Zhejiang University School of Medicine

3. 1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China

Abstract

Abstract The association of cholinergic basal forebrain (cBF) degeneration and olfactory function in Parkinson’s disease (PD) is unclear. We analyzed free water (FW) values in the cBF of participants from the PPMI dataset, and found increased FW values in the nucleus basalis of Meynert (NBM) were correlated with worse olfaction in patients with PD. FW in the NBM has the potential to provide early biomarkers of olfaction dysfunction in patients with PD.

Publisher

Research Square Platform LLC

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