Abstract
Abstract
Purpose
Our study aimed to determine the possible factors that might impact the probability of obtaining a euploid blastocyst following intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A) procedures in idiopathic recurrent pregnancy loss (RPL) patients.
Methods
This single-center retrospective cohort analysis included 180 oocyte retrieval cycles of 166 women under 35 years old and those diagnosed with idiopathic RPL according to American Society of Reproductive Medicine (ASRM) guidelines. Trophectoderm biopsy and next-generation sequencing (NGS) were the techniques used. Patients were stratified by the number of previous losses (Group A: 2, Group B: 3, and Group C: >3).
Results
Baseline and embryological characteristics showed no statistically significant differences. The euploidy rate per analyzed blastocyst was comparable within the groups (63.3%, %, 58.2%, and 58.5%; p = 0.477). Logistic regression analyses confirmed that only the trophectoderm scores of A and B increased the probability of obtaining a euploid embryo [OR: 1,82, 95% CI: (1,120-2,956); p: 0,016].
Conclusion
It is concluded that there was no correlation between the number of previous losses and the chance of finding at least one euploid embryo in ICSI cycles of women younger than 35 years old.
Publisher
Research Square Platform LLC
Reference37 articles.
1. Definitions of infertility and recurrent pregnancy loss: a committee opinion;Practice Committee of the American Society for Reproductive Medicine;Fertil Steril,2020
2. Effect of prior birth and miscarriage frequency on the prevalence of acquired and congenital uterine anomalies in women with recurrent miscarriage: a cross-sectional study;Jaslow CR;Fertil Steril,2013
3. Evaluation and treatment of recurrent pregnancy loss: a committee opinion;Practice Committee of the American Society for Reproductive Medicine;Fertil Steril,2012
4. A cytogenetic study of repeated spontaneous abortions;Hassold TJ;Am J Hum Genet,1980
5. Drugan A, Koppitch FC 3rd, Johnson JC, Moghissi MP, Evans KS (1990) MI Prenatal genetic diagnosis following recurrent early pregnancy loss. Obstet Gynecol. 75(3 Pt 1):381-4