Surgical outcomes of very-early-onset ulcerative colitis: retrospective comparative study with older pediatric patients

Author:

Fumita Takashi1,Terui Keita1,Shibata Ryohei1,Takenouchi Ayako1,Komatsu Shugo1,Oita Satoru1,Yoshizawa Hiroko1,Hirano Yuichi1,Yoshino Yusaku1,Saito Takeshi2,Hishiki Tomoro1

Affiliation:

1. Department of Pediatric Surgery, Graduate School of Medicine, Chiba University

2. Department of Pediatric Surgery, Chiba Children's Hospital

Abstract

Abstract Purpose The study compares the surgical outcomes of very-early-onset ulcerative colitis (VEO-UC), which is a rare disease diagnosed in pediatric patients < 6 years, with those of older pediatric patients with ulcerative colitis (UC). Methods A retrospective observational study of 57 pediatric patients with UC was conducted at a single center. The study compared surgical complications and postoperative growth between the two groups. Results Out of the 57 patients, 6 had VEO-UC, and 5 of them underwent total colectomy. Compared with the surgical cases of older patients with UC (n = 6), the rate of postoperative complications in patients with VEO-UC (n = 5) was not significantly different, except for high-output ileostomy (80% vs. 0% at 3 weeks postoperatively, p = 0.02). The rate of postoperative central venous catheter (CVC) placement at > 90 days was higher in patients with VEO-UC (100% vs. 17%, P = 0.02). The median change in the Z-score of height before and 2 years after colectomy was not significantly different between VEO-UC and older patients (1.1 vs. 0.3, p = 0.13). Conclusion With regards complications and outcomes, total colectomy for VEO-UC patients and that for older pediatric UC patients is comparable. However, high-output ileostomy and long duration of CVC placement may pose management challenges.

Publisher

Research Square Platform LLC

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