Affiliation:
1. Isfahan University of Medical Sciences
Abstract
Abstract
Introduction: Laryngoscopy and tracheal intubation lead to an increase in the sympathetic reflex response, which is associated with an increase in heart rate and blood pressure. This response can be harmful in high-risk patients. The aim of this study is to investigate the effects of etomidate compared with midazolam and sodium thiopental in weakening the sympathetic response to laryngoscopy and tracheal intubation. Methods: This double-blind clinical study was conducted in 2020 at Al-Zahra Hospital in Isfahan on two groups of 39 candidates for elective surgery under general anesthesia. Anesthesia was induced by etomidate (E) 0.3 mg/kg in the first group and sodium thiopental 2.5 mg/kg and midazolam 0.075 mg/kg in the second group (TM), then the patient was intubated. Laryngoscopy findings and cardiovascular response were evaluated during the study and finally the data were analyzed using SPSS version 23. (IBM SPSS, Armonk, NY, USA). Results: There was no significant difference between the two groups in terms of age (P = 0.82), weight (P = 0.42), height (P = 0.201), body mass index (P = 0.78), gender (P = 0.65), American Society of Anesthesiologists (ASA) physical status (P = 0.36) and laryngoscopy view grading (P = 0.83). The average laryngoscopy time in E group was less than TM group (P = 0.019). In the TM group at 10 minutes after intubation, mean diastolic blood pressure (P = 0.029) and mean arterial blood pressure (P = 0.023) were significantly lower, but at other times there was no significant difference between the two groups (P > 0.05).There was no significant difference between the two groups in terms of adverse responses to laryngoscopy and intubation (P = 0.19). Conclusion: The results of this study showed that the cardiovascular response to laryngoscopy and tracheal intubation in both groups is similar and it seems that TM instead of E can be used as needed.
Publisher
Research Square Platform LLC