Remineralization of teeth with Casein Phosphopeptide-Amorphous Calcium Phosphate - Analysis of salivary pH and the rate of salivary flow

Abstract

Abstract Aim To evaluate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in remineralization of teeth of Syrian children aged 6–8 years enrolled in orphanage of the city of Damascus. Methods This study is part of a double-blind randomized controlled clinical trial. It included 50 children randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 minutes, saliva samples were collected four times (T0, T1, T2, and T3) to measure salivary pH and the rate of salivary flow. Results There was no significant difference between group A and B in the mean value of salivary flow rate and salivary pH. However, there was a significant difference between different time points in the mean value of salivary pH and salivary flow rate. Conclusion The application of the GC Tooth Mouse (CPP-ACP) may not be effective for the remineralization of teeth of children as it was similar to placebo in increasing the salivary pH and salivary flow rate. Other alternatives should be considered. Trial registration: ISRCTN17509082, Registration date 22/11/2022