Pulmonary adverse reaction caused by furazolidone: A report of two cases and literature review

Abstract

Abstract Purpose Drug-induced lung injury, defined as lung injury due to specific drug use, is an adverse reaction that occurs specifically in the pulmonary system, including the lungs, bronchi, pulmonary blood vessels, and pleura. There are currently few reports of furazolidone-mediated lung injury. We emphasize that when symptoms such as fever, cough, sputum production, chest tightness, increased eosinophils, interstitial changes in lung imaging with thickening of interlobular septa occur after the application of furazolidone, adverse pulmonary reactions caused by furazolidone can be considered. Methods and results We report a case series consisting of two patients with adverse pulmonary reactions occurring after the use of furazolidone and a current review of all previous reported adverse pulmonary reactions related to furazolidone. Conclusion As furazolidone may cause adverse pulmonary reactions, clinical vigilance is warranted to prevent adverse consequences. If this adverse reaction is found, furazolidone should be stopped in a timely manner. If the eosinophil count continues to be higher than normal after discontinuation, hormone therapy is needed.