Affiliation:
1. College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics , Fujian Medical University
2. Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect
3. Department of Plastic Surgery, the Third Affiliated Hospital of Zhengzhou University
Abstract
Abstract
Introduction
Thalassemia, an inherited quantitative globin disorder, is the most prevalent monogenic disease globally. While severe alpha thalassemia results in intrauterine death, β-thalassemia manifests during childhood due to the "second conversion of hemoglobin," garnering increased attention in recent decades.
Methods
In this study, a bibliometric analysis will be conducted of thalassemia articles published in the Web of Science Core Collection database between 2013 and 2023 to establish a comprehensive overview and to identify emerging trends. A total of 5655 studies published between 2013 and 2023 were systematically retrieved, and annual publications demonstrated a steady increase, maintaining a high level over the past decade.
Results
The United States contributed the highest number of publications, followed by China. Notably, the journal Blood emerged as the leading authority in β-thalassemia research. Analysis of research hotspots revealed that the pathogenesis of β-thalassemia is primarily linked to iron overload, anemia, gene mutations, and ineffective erythropoiesis. Furthermore, recent studies focusing on gene editing therapies present promising avenues for future investigation.
Conclusion
These findings grasp the research status of β-thalassemia and shed new light on future research frontiers.
Publisher
Research Square Platform LLC