Abstract
Background
Choledochal cysts are congenital glitches categorized by dilatation of the bile ducts, which can arise in various forms distressing the intrahepatic, extrahepatic, or both parts of the biliary tree. The purpose of our study was to observe the relationship between the dilatation of intrahepatic and extrahepatic bile ducts and prognosis.
Methods
A total of 79 cases in which patients had undergone laparoscopic choledochal cyst excision surgery were conducted from August 2016 to October 2020 at a single Centre of the Children’s Hospital of Zhejiang University of School of Medicine. There was a total of 64 females and 15 males. The age ranged from 21 days to 14 years, with an average age of 2 years. Choledochal cysts were recorded retrospectively for their age, gender, clinical presentation, physical, laboratory, and histological findings, diagnostic methods, and operative procedures.
Results
Results revealed that ALT and AST (< 0.001) and PT (0.005), GGT (0.004), total bile acid (0.019) and blood Amylase (0.024) were statistically significant with the presence of intrahepatic or extrahepatic bile duct dilation with insignificant demographics features and PT (0.040), ALT (0.002), AST (0.007) and total bile acid (0.021) were considered to be statistically significant predictors. Similarly, in the presence of bile duct dilation, ALT (< 0.001) and AST (< 0.001) were statistically highly significant, whereas the rest of the indicators were found to be insignificant. In terms of Odds Ratio ALT and AST gave the lowest CI (95% of the confidence interval). In contrary, C- reactive Protein “CRP” showed the highest CI (95% of the confidence interval) which is (1.78), and PT comes after by showing (0.50) confidence interval.
Conclusions
Thus, it is statistically confirmed that PT and CRP exposure variables have the lowest risk factor of the presence of both intra and extrahepatic bile duct dilations in our 79 patients. Since the small CI indicates a higher precision of the OR, the ALT and AST exposure variables determine that it has a higher risk factor of the presence of intrahepatic and extrahepatic bile duct dilatations of the given respondents in this study Moreover, the research highlights the crucial significance of understanding the correlation between choledochal cysts, intrahepatic bile duct dilations, extrahepatic bile duct abnormalities, and their influence on prognosis. Accurate classification and early intervention are crucial for improving long-term outcomes and reducing the risk of complications.