The relationship between hematological parameters and bronchopulmonary dysplasia in premature infants

Abstract

Abstract AIM To evaluate the association between hematological parameters on the first day and bronchopulmonary dysplasia (BPD) in preterm infants and to help with early warning, identification, and intervention in the development of BPD. METHODS This is a retrospective study of all premature infants admitted to neonatal intensive care From January 2017 to June 2022, BPD was diagnosed as hypoxia exposure over 28 days, and levels of neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio༈PLR༉, Platelet count༈PLT༉, Mean platelet volume༈MPV༉and Platelet mass index༈PMI༉ were determined in all groups. Multivariate analysis was conducted to evaluate the independence of the association between the hematological parameters on the first day and the risk of BPD. RESULTS In our research 76 cases of non-BPD and 48 cases of BPD were used as controls. Compared with the non-BPD group, NLR levels were considerably higher in the BPD group, nevertheless, PLT and MPI were lower than those of non-BPD. Logistic regression analysis suggested that NLR、PLT and PMI were independent risk factors for BPD(OR: 1.15; 95% CI: 1.04–1.28; P < 0.05; OR: 0.65; 95% CI: 0.47–0.89; P < 0.05; OR: 0.90; 95% CI: 0.81-1; P < 0.05). CONCLUSION Our findings suggest that hematologic parameters on the first day are different who will develop BPD. A higher NLR and a lower PLT, PMI on the first day may increase the risk of BPD.