Cellulose based electrospun nanofibrous scaffolds as a novel transdermal patch; Survey on their thermophysical and biological proficiencies

Abstract

AbstractCellulose derivatives due to their biocompatibility, bioactivity and biomechanics are among the most used resources for biomedical applications. In this study mats using different amounts of cellulose acetate (CA)/polyvinylpyrrolidone (PVP)/ polyvinyl alcohol (PVA) of blended nanofibers were prepared via co-electrospinning technique by employing double nozzle for jetting solutions of CA/PVP and PVA, separately. The chemical structure, morphology, thermal stability and tensile analyses of the prepared nanofibrous samples were fully characterized. Moreover, MTT assay and cell culture studies using human skin fibroblast cell lines were also carried out to determine the cytocompatibility, viability and proliferation of the cells on the surface of the prepared scaffolds. To survey on the release kinetics,ex-vivoskin permeation studies were performed on the mat with the most suitable ratio, using Franz cell diffusion system. According to the obtained thermophysical and biological results, the synthesized electrospun nanofibrous mat unveil great potentials in biomedical applications especially in cell culture, tissue engineering and also as a drug loaded transdermal patch.