Glutathione attenuates copper levels and alleviates hepatic injury in TX mice

Author:

Wang Mengzhen1,Hu Qiang1,Wang Ni1,Jiang Yuge1,Dong Ting2,Cao Shijian2,Zhou An1

Affiliation:

1. Anhui University of Chinese Medicine

2. The First Affiliated Hospital of Anhui University of Chinese Medicine

Abstract

Abstract

Wilson's disease(WD) is an inherited disorder of abnormal copper metabolism, and promotion of copper ion excretion is the focus of its treatment in the clinic. Glutathione (GSH) is a tripeptide compound whose active group is the sulfhydryl group, which is involved in a number of important biochemical reactions. Thus, its antioxidant and integrative detoxification effects have attracted interest. Whether glutathione promotes copper ion excretion and anti-oxidative stress to alleviate Wilson's disease liver injury is the focus of this study. Here, we used toxic milk(TX) mice as model mice to study Wilson's disease and treated them with glutathione. We observed that glutathione was effective in promoting copper excretion in TX mice. In addition, glutathione has been shown to be effective in attenuating liver injury, including improving the structure and morphology of stem tissue and reducing hepatocyte necrosis. The effects of glutathione on hepatic oxidative stress as measured by catalase, malondialdehyde and total superoxide dismutase. The results showed that glutathione could increase hepatic antioxidant enzyme activities, reduce lipid peroxidation levels and attenuate liver injury. In conclusion, glutathione may exert its hepatic benefits by promoting copper ion excretion and anti-oxidative stress.

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3