Diadema Setosum Chemical Compounds With Gc-ms Analysis as a Triple Inhibitor Antiviral Covid-19

Author:

Nugroho Endik Deni1,Sururi Ahmad Misbakhus2,Rahayu Dwi Anggorowati2,Ardiansyah Reza1,Kurniwawan Nia3,Widodo Widodo3

Affiliation:

1. Institut Teknologi & Sains Nahdlatul Ulama Pasuruan, Pasuruan Regency

2. Negeri Surabaya University

3. University Brawijaya

Abstract

AbstractMarine echinoderms, specifically the sea urchin speciesDiadema setosum, may hold promise in the medical field as potential sources of antiviral agents for Covid-19. Recent research focused on identifying the compounds within their extracts and their effectiveness as inhibitors for the 3CLpro, RdRp, and ACE2 proteins throughin silicomodelling. This research begin with extraction and GC-MS analysis to identify the contents of the extract; the identified compounds were analyzed by molecular docking to determine their potential as antivirals. A compound exhibited a favourable Lipinski profile and low toxicity prediction, suggesting its potential as a viable antiviral candidate. The results showed that there was one compound, namely 5H-Isoindole[1,2-b][3]benzazepine-5-one, 7,8,13,13a-tetrahydro-10-hydroxy-3,4,12-trimethoxy- which has the potential to as an antiviral with the support of druglikeness profile and prediction of its toxicity. While additional research is necessary to comprehend its therapeutic potential fully, the study's findings showcase the compound's potency as a promising antiviral agent.

Publisher

Research Square Platform LLC

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