CXCL5 and CXCL14, but not CXCL16 as potential non-invasive biomarkers of colorectal cancer?

Abstract

Abstract Purpose Experts emphasize that incidence and mortality of colorectal cancer (CRC) is increasing. That is why, its early detection is of utmost importance. Patients with cancer diagnosed in earlier stages have better prognosis and chance for faster implementation of treatment. Consequently, it is vital to search for new parameters that could be useful in its diagnosis. Methods Therefore, we evaluated the usefulness of CXCL5, CXCL14 and CXCL16 in serum of 115 subjects (75 CRC patients and 40 healthy volunteers). Concentrations of all parameters were measured using Luminex. CRP levels were determined by immunoturbidimetry, while levels of classical tumor markers were measured using CMIA. Results Concentrations of CXCL5 were statistically higher in CRC group when compared to healthy controls. The diagnostic sensitivity, specificity, positive and negative predictive value, and area under the ROC curve (AUC) of CXCL5 and CXCL14 were higher than those of CA 19 − 9. Conclusions Obtained results suggest the usefulness of CXCL5 and CXCL16 in the determination of distant metastases and differentiation between TNM stages, as well as usefulness of CXCL14 and CRP combination in CRC detection. However, further studies concerning their role in CRC progression are crucial to confirm and explain their diagnostic utility and clinical application as biomarkers.