Abstract
Purpose
The systemic inflammatory response is a significant prognostic indicator in patients with cancer. Few studies have reported a relationship between postoperative systemic inflammatory responses and prognosis in patients with gastric cancer. This study aimed to clarify the efficacy of postoperative systemic inflammatory response in patients with gastric cancer after gastrectomy and to determine which prognostic scoring system is better.
Methods
Overall, 210 patients with gastric cancer who underwent gastrectomy between February 2013 and July 2022 were included. Systemic inflammatory response markers, including the Glasgow prognostic score, prognostic nutritional index, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio, were calculated before and 1 month after surgery. The relationship between preoperative and postoperative systemic inflammatory responses and the prognosis of patients with gastric cancer was investigated.
Results
In multivariate analysis, postoperative Glasgow prognostic score of 1or 2 (P = 0.04, P < 0.01, respectively), stage II or III (P < 0.01, P < 0.01, respectively), and R1 or R2 curability (P = 0.03, P < 0.01, respectively) were independent and significant predictors of disease-free survival and overall survival. Eighty-seven patients (41%) were classified as having postoperative Glasgow prognostic scores of 1 or 2. Patients with a postoperative Glasgow prognostic score of 1 or 2 had significantly more advanced tumors, more invasive surgery, and more postoperative complications than those with a postoperative Glasgow prognostic score of 0.
Conclusion
The postoperative Glasgow prognostic score was independently associated with poor prognosis and recurrence in patients who underwent gastrectomy for gastric cancer comparing other pre- and post- operative prognostic scoring markers.