Platelet to Lymphocyte Ratio as an Inflammatory Marker in Perthes disease

Abstract

Abstract Objective: To investigate the relationship between NLR(lymphocyte ratio), PLR(platelet to lymphocyte ratio), LMR(lymphocyte to monocyte ratio) and PNS(platelet to neutrophil ratio) and the lateral pillar classificationof Perthes disease, and to provide an alternative index for clinical diagnosis and prognosis. Methods: 59 children with Perthes disease and 60 children in the healthy control group without femoral head necrosis in our hospital from 2012 to 2021 were collected. The general data were collected. The modified herring lateral pillar classification was collectedfor the case group, and the inflammatory factors NLR, PLR, LMR and PNS were collected. The cases were divided into three groups, herring A and B were group I, herring B/C and C were group II, and the healthy control group was group III. The hematological indexes (NLR, PLR, LMR, PNS) of children at different stages were statistically analyzed. Results: Group I consisted of 36 patients, with an average age of 7.4 ± 2.0 years (3–11 years). Group II consisted of 23 patients, with an average age of 7.4 ± 1.9 years (4–12 years). Group III consisted of 60 patients, with a mean age of 7.4 ± 2.7 years (4–13 years). The average values of PLR in groups I, II and III were 131.98 ± 47.44, 122.19 ± 37.88 and 102.46 ± 30.68, respectively. It's worth noting that there was statistically significant difference among these groups (P=0.003). The optimal threshold of PLR was 130.25, the sensitivity was 45.8% and the specificity was 85%. Conclusion: PLR has certain value in the diagnosis of Perthes disease. The higher the value of PLR, the higher the risk of Perthes disease.