The Interactions and Biological Pathways Among Metabolomics Products of Patients with Coronary Heart Disease Analyzed Using the Bioinformatics Methods

Abstract

Abstract Background: Metabolome products are small molecules resulting from cellular metabolism. Studies has used advanced methods of molecular detection to analysis samples of ill patients. Based on bioinformatics analysis, the interactions and biological pathways among metabolome products in patients with coronary heart disease (CHD) were investigated. Methods: Related studies focusing on the metabolomics analysis of patients with CHD published on CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Nature, Web of Science, Spring, and Science Direct were retrieved. The metabolites in the literature were analyzed statistically and summarized, the differential metabolites were selected and their pathways were analyzed based on the Kyoto Encyclopedia of Genes and Genomes (KEGG). Molecular annotation of metabolites and related enzymes or transporters were analyzed with the HMDB. Their related properties were visualized using the metPA. Results: A total of 12 literatures which satisfying the criteria for enrollment were included here. Total 136 metabolites related to CHD were preliminarily screened, and 83 effective metabolites were obtained after the unrecognized metabolites were excluded. 45 pathways were involved. Through the topology analysis (TPA) of pathways, their influence values were calculated, and 14 major metabolic pathways were selected, which were phenylalanine (Phe), tyrosine and tryptophan biosynthesis (TTB), Aminoacyl-tRNA biosynthesis (ATB), and arginine biosynthesis (ABS). These results indicated that glucose metabolism, fatty acid (FA) metabolism, amino acid (AA) transporting to proteins to cells, and tricarboxylic acid (TCA) cycle were involved in the occurrence of CHD. Conclusion: this study showed cellular and molecular pathways involved in the process of CHD. This information can be used for different drug development and diagnostic studies.