Contribution of prophylactic administration of flurbiprofen for mesenteric traction syndrome to postoperative leakage or bleeding in gastrointestinal surgery: a retrospective observational study

Abstract

Abstract Purpose Mesenteric traction syndrome sometimes occurs during abdominal surgery. Prophylactic administration of flurbiprofen, a non-steroidal anti-inflammatory drug, prevents the development of mesenteric traction syndrome. However, administration of non-steroidal anti-inflammatory drugs for postoperative pain increases the incidence of postoperative bleeding. Our aim was to examine the effect of prophylactic flurbiprofen administration on postoperative leakage or bleeding after gastrointestinal surgery. Methods A retrospective observational study on patients who underwent open or laparoscopic abdominal surgery was conducted. Perioperative, anesthesia and medical records were reviewed. Patients who did (Group F) or did not receive (Group C) prophylactic flurbiprofen administration were compared. Then, Group F (Group FM and Group FC) and Group C (Group CM and Group CC) were each divided into patients who did or did not develop mesenteric traction syndrome, respectively. Results This study included 188 patients (Group FM, 1 patient; Group FC, 31 patients; Group CM, 59 patients; Group CC, 97 patients). Seventeen patients developed postoperative leakage or bleeding. Eleven group CM patients (18.6%), 4 group FC patients (12%), and only 2 group CC patients (2%) developed postoperative leakage or bleeding. Conclusion Prophylactic flurbiprofen administration increased the risk of postoperative leakage or bleeding among patients who did not develop mesenteric traction syndrome.