Incidence, predictors and outcomes of cardiac perforation during paediatric cardiac catheterization: A retrospective observational study from the Congenital Cardiac Interventional Study Consortium (CCISC)

Abstract

Abstract Introduction Cardiac perforation is a rare life-threatening complication of cardiac catheterization. There is very little published literature detailing risk factors for cardiac perforation and outcomes from this complication in children. Materials and Methods This was a retrospective study analyzing the cardiac catheterization case registry of the Congenital Cardiovascular Interventional Study Consortium. Children aged <18 years were included during the study period of 9 years (January 2009- December 2017). The primary outcome measures were incidence of cardiac perforation, risk factors for and outcomes of patients who experience cardiac perforation during cardiac catheterization. Results Cardiac perforation occurred in 50 patients from a total of 36,986 (0.14%). Cardiac perforation was more likely to occur in younger, smaller patients undergoing urgent /emergent and interventional procedures (p<0.01). Cardiac peroration risk was significantly different across diagnostic and procedure categories (p<0.01). Higher CRISP score (Area Under Curve [AUC] =0.87), lower age and procedure category (radio-frequency perforation of pulmonary valve, AUC =0.84) were independent predictors of cardiac perforation. Cardiac perforation was associated with a significantly higher rate of mortality (14%), further emergency procedure (42%), ECMO (14%) and cardiac arrest (6%), p<0.01. Conclusions Cardiac perforation during cardiac catheterization is a life-threatening complication with a range of associated secondary complications. Higher CRISP score, lower age and radio-frequency perforation of pulmonary valve are independent predictors.