Correlation analysis of serum exosomal miR-133a-3p, miR-206, and miR-549a-3p with diagnosis and prognosis in patients with traumatic head injury

Abstract

Abstract Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Our research team previously used high-throughput sequencing to reveal the significant differences of serum exosomal miR-133a-3p, miR-206, and miR-549a-3p were significantly different from the control group in the severe TBI (sTBI), mild or moderate TBI (mTBI), and control groups. However, there is a lack of convincing experimental evidence. To address this, the present study experimentally sought to verify Our current study verifies the potential of serum exosomes miR-206 and miR-549a-3p as potential biomarkers in TBI patients and their association with inflammatory response and oxidative stress through real-time fluorescence quantification, enzyme-linked immunosorbent assay, and statistical analysis.