Affiliation:
1. Christian Medical College and Hospital
2. Christian Medical College, Vellore
3. London School of Hygiene and Tropical Medicine
Abstract
Abstract
Purpose
To estimate the prevalence and determine predictors of lens opacities (LO) among South Asian Indians aged 41-44 years.
Methods
This cross sectional study included 1080 participants from the Vellore Birth Cohort, Vellore, South India. All individuals underwent anthropometric measurements, detailed ophthalmic examination including assessment of LO by LOCS III classification; and biochemical metabolic measurements. ‘Any cataract’ was defined as any opacity type with a score of >2 or evidence of cataract surgery in either eye. Questionnaire based assessments included information on ocular history, life-style factors, socio-economic and educational status, cooking fuel and sunlight exposure. Multivariable logistic regression analysis was used to examine the association between risk predictors and LO.
Results
The mean age (SD) of participants was 41.8 (1.0) years; 53.8% were male and 50% were rural residents. The overall prevalence of ‘any cataract’ was 13.8% (148/1075); 95% confidence interval (CI) (11.8,16.0); 59.1% (51.1, 67.4) had nuclear, 16.9% (11.2, 23.9) had cortical, 4.1%(1.5, 8.6) had posterior sub capsular, 18.9% (12.9, 26.2) had mixed cataracts; and 0.7% ( 0.02, 3.7) were pseudophakic.
Increased risk for LO was observed with a history of asthma (aOR 4.51; 2.1, 9.7), HbA1C of ≥6.5% (adjusted or aOR 2.29; 95%CI 1.4, 3.7), hypertension (aOR 1.73;1.1, 2.7) and, in a subgroup (n= 372), lower 25(OH) vitamin D levels (≤20 ng/dL)(aOR 5.56; 2.3, 13.2).
Conclusions
A higher prevalence of LO at a younger age in South Asian Indians predicts earlier onset. History of asthma, higher HbA1C, hypertension and lower 25(OH) vitamin D levels were associated with LO.
Publisher
Research Square Platform LLC
Reference72 articles.
1. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis;Bourne RRA;Lancet Glob Health
2. The Lancet Global Health Commission on Global Eye Health: vision beyond 2020;Burton MJ;Lancet Glob Health,2021
3. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis;Flaxman SR;Lancet Glob Health,2017
4. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017;Collaborators GDaIIaP;Lancet,2018
5. 2002 global update of available data on visual impairment: a compilation of population-based prevalence studies;Pascolini D;Ophthalmic Epidemiol,2004