Thermodynamics and Micellar Behavior of Surface-Active Drugs in Aqueous Solution of Electrolytes: Surface Tension Study-Reference-Cited by-同舟云学术

Thermodynamics and Micellar Behavior of Surface-Active Drugs in Aqueous Solution of Electrolytes: Surface Tension Study

Published:2022-09-16 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Sharma Sapna¹,Kumar Kuldeep¹,Sharma Saurabh¹,Thakur Naveen¹,Singh Kuldeep²,Chauhan Suvarcha³

Affiliation:

1. Career Point University Hamirpur (H.P.)

2. MCM DAV College Kangra (H.P.)

3. Himachal Pradesh University

Abstract

Abstract The surface tension study of the surface-active drugs streptomycin sulphate and diphenhydramine hydrochloride has been carried out with three uni-univalent and three bi-univalent electrolytes viz. NaCl, KCl and RbCl (0.01 mol.kg-1), and MgCl2, CaCl2 and SrCl2, (0.002 mol.kg-1) at temperature range of 298.15 to 313.15 K. The interfacial parameters like maximum surface excess concentration ( Γmax), minimum area per surfactant molecule (Amin), and surface pressure at CMC (Πcmc) have been explored. The results represent the stronger affinity between drug-electrolyte molecules, which lower the surface tension values. The CMC relations govern the hydrophobic and hydrophilic interactions in ternary system (water-drug-electrolyte). Further, the addition of electrolytes lowers the total number of drug molecules at the interface, correlated with increase in Amin, and decrease in Γmax and Πcmc. Thermodynamics of micellization directs about the work done for micellization, and lighten the surface and bulk properties of drugs.

Publisher

Research Square Platform LLC

Reference47 articles.

1. 1. S. Mignani, J. Rodrigues, H. Tomas, R. Jalal, P.P. Singh, J.P. Majoral, R.A. Vishwakarma, Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?, Drug Discov. Today. 23 (2018) 605–615. https://doi.org/10.1016/j.drudis.2018.01.010.

2. 2. M. Abdul Rub, D. Kumar, Micellization Behavior of Antidepressant Imipramine Hydrochloride Drug and Hydrotrope (Sodium Tosylate) Mixtures at Different Compositions and Temperatures in Different Media, J. Chem. Eng. Data. 65 (2020) 2659–2672. https://doi.org/10.1021/acs.jced.0c00038.

3. 3. S. Chauhan, M. Kaur, Modulation of Aggregation Behaviour of Anionic Surfactant in the Presence of Aqueous Quaternary Ammonium Salts, J. Surfactants Deterg. 20 (2017) 599–607. https://doi.org/10.1007/s11743-017-1949-5.

4. 4. S. Chauhan, S. Kumari, K. Kumar, A. Umar, C.N. Sundaresan, R. Gupta, Influence of iso-perthiocyanic acid and temperature on the aggregation properties of sodium dodecylsulphate in dimethylsulphoxide, J. Mol. Liq. 211 (2015) 338–345. https://doi.org/10.1016/j.molliq.2015.07.017.

5. 5. U. Farooq, A. Ali, R. Patel, N.A.N.A.A. Malik, Interaction between amphiphilic antidepressant drug nortryptyline hydrochloride and conventional cationic surfactants: A physicochemical study, J. Mol. Liq. 233 (2017) 310–318. https://doi.org/10.1016/j.molliq.2017.03.032.