Abstract
We aimed to investigate the influence of false lumen (FL) status on systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 AAD patients. Patients were divided between those with a thrombosed FL (Group T, n=21) and those with a non-thrombosed FL (Group P, n=23). On-admission serum concentrations of 29 cytokines were compared between unmatched and propensity-score matched (n=10 pairs) FL groups and a control group (non-ruptured thoracic aortic aneurysm, Group C, n=20). Unmatched analysis showed twelve cytokines differed between groups and fell into three categories: Category A (increased expression in both FL groups: IL-6, IL-10, IL-15, G-CSF); Category B (increased expression only in Group P: IL-1Ra, IL-1β, IL-8, IL-12p70, GM-CSF); and Category C (others: IP-10, VEGF-A, eotaxin). The increases in Category A and Category B cytokines in Group T were attenuated, but not significantly, compared to their increases in Group P. Propensity-score matching analysis revealed a similar expression pattern with respect to all four Category A cytokines, four Category B cytokines (IL-1β, IL-1Ra, IL-12p70, and GM-CSF), and two Category C cytokines (IP-10 and VEGF-A). A robust inflammatory response occurs in patients with AAD, but the response is attenuated when the FL is thrombosed.