Bioinformatics analysis highlights CCNB1 as a potential prognostic biomarker and an anti-kidney renal papillary cell carcinoma drug target

Abstract

Abstract Kidney renal papillary cell carcinoma (KIRP) is a common tumor in the urinary system, which is easy to cause lymph node invasion. Once metastatic, the prognosis is poor, and there is a lack of effective early diagnostic markers for this tumor. We used R language to process the data from TCGA and GTEx combined with multiple online databases. Sensitive drugs targeting CCNB1 were screened out by the ‘pRRophetic’ package and molecular docking technology. Our data indicated that the expression level of CCNB1 in KIRP was significantly higher than that in normal tissues. This result was validated at the IHC level through the HPA database. In addition, the CCNB1 was also significantly increased with the progression of the T and M stages. The patients with higher CCNB1 expression had a poor prognosis in KIRP. CCNB1 was also an independent prognostic factor for KIRP. What’s more, CCNB1 was associated with immune infiltration. Finally, we also screened out five drugs targeting CCNB1. Our results showed that CCNB1 is a potential and reliable diagnostic biomarker for KIRP and it is a good predictor of KIRP survival. The five selected drugs targeting CCNB1 may bring good social value to patients with KIRP metastasis.