Efficacy of adipose-derived stem cells combined with different scaffolds to repair bone defects: a systematic review and Meta-analysis

Abstract

Abstract At the present stage, the most traditional techniques for the treatment of bone defects often fail to achieve the desired results. The tissue engineering technology about bone regeneration emerged as a new method for treating bone defects. Cells and scaffolds are the two most important key factors in tissue engineering, and there are many types of scaffolds are already in use in experiments. And there are so many studies are now on different Cellular scaffolds filled with ADSCs (adipose-derived stem cells). But these researches are still in the animal experimental stage. This study informed the clinical application of ADSCs through an evidence-based medicine analysis to evaluate the efficacy of ADSCs in repairing the bone defect. We systematically searched databases, collected relevant studies, and screened them, then analyzed the data using specialized tool and rated the credibility of the results at the end. The final results concluded that the efficiency of treatment of ADSCs combined with scaffold treatment group was superior to the control group. Quality of evidence (GRADE): high. The combination of ADSCs with cellular scaffolds may be effective in promoting repair of bone defects. However, additional, more demanding experiments are still needed to test the effect of ADSCs on bone regeneration.