Lipid metabolism disturbances in papillary thyroid cancer patients and the relationship with iodine nutrition status

Author:

Zhai Yuqian1,Wang Xuebin1,Luo Jie1,Wang Xueqian2,Liu Zhonghao2,Wang Junrong2,Liu Zhiyong1,Mao Xionghui2,Fan Lijun1

Affiliation:

1. Chinese Center for Disease Control and Prevention, Harbin Medical University

2. The Harbin Medical University Cancer Hospital, Harbin Medical University

Abstract

Abstract Objective: Cancer patients are frequently accompanied by problems in lipid metabolism. Uncertainty exists as to whether changes in serum lipids occur in patients with papillary thyroid cancer (PTC) and their relationship with iodine nutrition remains obscure. The aim of this study was to explore lipid metabolism disturbances in PTC patients and their relationship with iodine nutrition status. Methods: A total of 909 patients who were initially diagnosed with PTC and 183 patients who were initially diagnosed with benign thyroid nodules were enrolled in this study. The serum iodine concentration (SIC), the urine iodine concentration (UIC) and nine serum lipids indicators were measured. The generalized linear model (GLM) together with other statistical methods were used to determine whether there were differences in serum lipids between patients with PTC and those with benign thyroid nodules. Results: After adjusting for baseline information, triglycerides (TG) levels in the control group (4.29±1.21) were significantly higher than in the cancer group (1.59±1.25). The rate of abnormal thyroid function was significantly lower in the patients with PTC than in the patients with benign nodules. In the PTC patients, different clinicopathological features had an impact on thyroid function, as reflected by a significant increase in FT3 in PTC with lymph node metastases, a significant increase in TSH, TGAb, and TPOAb, and a significant decrease in FT4 in PTC with AITD. Correlation analysis revealed weak to moderate correlations between iodine nutritional status, thyroid function, and serum lipids. In benign thyroid nodule patients, LDL-C and ApoB values in patients with benign thyroid nodules were significantly higher in the high SIC group than in the adequate and deficient groups. In PTC patients. ApoE levels in the low UIC group were significantly higher than in the middle and high UIC groups. Mediating effects were used to analyze the effect of iodine nutrition on the serum lipids, it showed that the total and direct effects of iodine nutritional status on serum lipids were significant, and the mediating effect of thyroid function was not significant. Conclusion: TG levels in the control group were significantly higher than in the PTC group. Iodine nutritional status influences lipids, and an excess or deficient iodine nutrition increases the risk of dyslipidemia in patients with thyroid nodule. Iodine nutritional status had a direct effect on serum lipids.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3