Abstract
Background and Aims:
Patients undergoing maintenance hemodialysis (MHD) experience increased mortality and cardiovascular disease (CVD) risks; however, the potential connection between pinch strength (PS) and the prognosis of these patients remains unknown. Consequently, this study aimed to comprehensively assess the influence of PS and handgrip strength (HGS) on both survival and cardiovascular events (CVE) in patients undergoing MHD, providing valuable insights for clinical decision-making.
Methods:
Data were gathered from patients undergoing MHD at the Hemodialysis Center of Guangzhou Red Cross Hospital in March 2021. We performed a retrospective follow-up spanning 24 months, utilizing death or CVE as the primary observation endpoints. Multifactorial Cox regression analysis, Kaplan–Meier survival curves, trend tests, and restricted cubic spline were applied to explore the association.
Results:
During a 24-month follow-up, data were collected from 140 patients undergoing MHD with an average age of 66.71±12.61 years. Among them, 52 (37.14%) experienced mortality, whereas 36 (40.00%) had CVE without baseline CVD at a mean age at onset of 63.87±12.74 years. Using the restricted cubic spline method, a linear connection was observed between PS and all-cause mortality. Adjusted analyses in different models revealed higher PS levels were independently associated with all-cause mortality but not with CVE risk (unadjusted HR, 0.90; 95% CI, 0.77–1.05). Kaplan–Meier survival curves demonstrated better survival rates and reduced CVE risk for patients in the second, third, and fourth quartiles compared with those in the first quartile for PS.
Conclusions:
PS was independently associated with all-cause mortality but not with CVE in patients undergoing MHD.