The diagnostic value of DCE-MRI quantitative analysis combined with PI-RADS v2.1 in prostate cancer

Abstract

Abstract Background: To explore the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters combined with the prostate imaging report and data system version 2.1 (PI-RADS v2.1) for prostate cancer (PCa). Methods: Retrospective collection of clinical data from patients with PCa who underwent DCE-MRI at Tongji Hospital Affiliated to Tongji University from June 2018 to January 2020, along with pathological results. Quantitative parameter (Ktrans, Kep and Ve) histograms were obtained through Siemens post-processing workstations. Receiver operating curve (ROC) were used to determine the optimal quantitative parameters, and logistic regression was utilized to establish a joint diagnostic model of quantitative parameters and PI-RADS score for patients with PCa. Results: The Ktrans and Kep (mean, 25th, 50th, and 75th) and Ve (25th) in the PCa group were higher than those in the non-tumor group (P<0.05). ROC results showed Ktrans 25th and Kep 50th had higher AUC, sensitivity and specificity for the diagnosis of PCa. Logistic regression analysis indicated the combined application of Ktrans 25th, Kep 50th and PI-RADS has higher application value in the diagnosis and invasiveness for PCa (P<0.05). Conclusions: The combined diagnostic model of Ktrans 25th, Kep 50th and PI-RADS have higher diagnostic efficiency in detecting PCa.