The hippocampal neuroinflammatory markers in intracerebroventricular streptozotocin injected rats are correlated with the memory impairments at different time points of post-injection.

Abstract

Abstract Intracerebroventricular (ICV) injection of streptozotocin (STZ) induces memory impairments and neuroinflammation in rats but the relation between neuroinflammation and memory impairments in ICV-STZ injected rats is not well understood. In the present study the memory impairments [working memory errors (WME) and reference memory errors RME)] in ICV-STZ injected rats were assessed with concomitant changes in the neuroinflammatory markers (TNF α, IL-1β, COX2, PGE2) in hippocampus at five different time points after ICV-STZ injection (3rd hour to 21st day post injection). Results showed that the WME and RME were increased gradually with time, and the neuroinflammatory markers were also gradually increased concomitantly after ICV STZ injection. These higher levels of the inflammatory markers are correlated with the memory impairments (WME and RME) and probably indicate a link between memory impairments and neuroinflammation.