Variability in resistance training trajectories of breast cancer patients undergoing therapy

Abstract

Abstract Purpose In resistance training (RT) the change in training volume from training sessions (TS) to TS, is an indicator of training progress. Resulting growth-trajectories are likely to differ between individuals. Understanding this variation is important for exercise planning in general, but even more for clinical populations. We investigated this variation in breast cancer patients undergoing treatment. Methods Data of 69 patients from two randomized controlled trails were investigated. They conducted a 12-week RT program. We fitted a quadratic Bayesian regression model to the baseline standardized training volume over the course of the intervention. We allowed all parameters to vary both between exercises and between individuals. Results We observed a positive linear component of 0.093 (95% Uncertainty interval (UI) 0.058 to 0.120) and a negative quadratic component of -0.002 (95% UI -0.008 to 0.001) for the mean trajectory of the change in training volume. For the different exercises we observed a dispersion for both the linear (0.043, 95% UI 0.018 to 0.082) and the quadratic component (0.002, 95% UI < 0.001 to 0.004). Variation between-individual appears to be approximately 4 times larger. We also observed between-exercise variation within individuals. Extrapolation of the regression model indicates training progression stagnates after 20.6 TS (95% UI 14.8 to 44.4). Conclusion There is substantial variation in RT response between breast cancer patients undergoing tumor therapy and in-between exercises. The non-linear trajectory indicates that training progression will eventually plateau, demanding periodization and timely modification. Trial Registration: BEATE Study: NCT01106820, Date: April 20, 2010; BEST Study: NCT01468766, Date: November 9, 2011