Comparing Dose-dependent Outcomes of Weekly and Daily Growth Hormone Therapy in Children with Growth Hormone Deficiency: A Systematic Review and Meta-analysis

Abstract

Abstract Background Growth hormone deficiency (GHD) is a condition impacting children and adults, leading to low height and other health issues. The primary treatment is daily injections of recombinant human growth hormone (rhGH), though they can be inconvenient and costly. These injections may also negatively impact treatment adherence and outcomes. This study aims to compare the efficacy and safety of once-weekly growth hormone treatment vs daily growth hormone therapy in children with growth hormone insufficiency. Methods To examine the efficacy and safety of once-weekly and once-daily growth hormone treatment for children with growth hormone insufficiency, this meta-analysis followed PRISMA and Cochrane standards. RCTs and prospective cohort studies with children aged 0–18 diagnosed with GHD were considered eligible. We used the risk of bias 2 and the certainty of evidence using the Cochrane tools. Two authors independently assessed papers for eligibility and extracted data after conducting a thorough search of electronic resources. Height velocity, height standard deviation score, insulin-like growth factor 1 levels, and the incidence of adverse events were the primary outcomes. The Revman software version 5.4 was used for data synthesis, and heterogeneity was determined by I-squares greater than 60%. Results This meta-analysis and comprehensive review includes 14 randomized clinical trials and one study was cohort, including 1,322 children with growth hormone insufficiency. Weekly growth hormone treatment at dosages ranging from 0.11 to 0.25 mg enhanced a variety of growth outcomes, including increased height velocity dose (SMD = 0.37, 95% CI, 0.23–0.51; P < 0.001), height standard deviation scores chronological age (SMD= -0.10, 95% CI, -0.13–0.07; P < 0.001), and insulin-like growth factor 1 standard deviation score (SMD = 0.41, 95% CI, 0.40–0.42; P < 0.001). The dosage range of 0.26 to 0.50 mg also improved insulin-like growth factor binding protein-3 significantly (SMD= -0.63, 95% CI, -0.90 – -0.37; P < 0.001). Nevertheless, there were no significant differences in the occurrence of adverse events through the dosage levels (OR = 0.71, 95% CI 0.36 to 1.40; P = 0.32). Conclusions In children with growth hormone deficit, weekly growth hormone treatment, particularly in the 0.11 to 0.25 mg dose range, can function as a viable alternative to daily growth hormone therapy.