Abstract
The purpose of this study is to investigate factors influencing the efficacy of Omidenepag Isopropyl (OMDI) in reducing intraocular pressure (IOP), and to compare its effects between patients with normal-tension glaucoma (NTG) and those with primary open-angle glaucoma (POAG). Eyes treated with OMDI, including 48 with NTG and 46 with POAG, were included. Data on visual acuity (VA), IOP, central corneal thickness (CCT), axial length (AxL), mean deviation (MD), visual field index (VFI), and retinal nerve fiber layer (RNFL) thickness were collected. Differences across groups (NTG vs. POAG, OMDI responders vs. non-responders, and HM(High myopia) vs. non-HM) were evaluated using independent t-tests for factors. Linear regression was used to identify factors associated with the IOP reduction efficacy of OMDI within the NTG and POAG groups. ANCOVA assessed mean IOP reduction differences between groups adjusting for other significant variables. In NTG patients, a negative correlation was observed between AxL with the IOP reduction effect of OMDI, while a positive correlation between baseline IOP and VA reduction with the percentage of IOP reduction was noted in both NTG and POAG groups. There was a trend toward greater IOP reduction effect by OMDI in NTG compared to POAG after adjusting for baseline IOP and AxL. In the NTG group, HM eyes showed a lower IOP reduction rate compared to non-HM eyes, following adjustments for baseline IOP.