Predictors and Highlights for pre- and post-exposure Prophylaxis Uptake among Men who have sex with Men in three large Cities in China

Abstract

Abstract Background Pre- and post-exposure prophylaxis (PrEP and PEP) haven’t been promoted among Chinese men who have sex with men (MSM) efficiently and nationally. As HIV prevalence among the population is high and increasing, it is urgent to facilitate PrEP and PEP promotion. This study aims to assess predictors for PrEP and PEP uptake and highlights for future promotion among MSM. Methods This cross-sectional study involved MSM in three large cities including Beijing, Shenzhen, and Kunming. We collected data by asking participants to scan a QR code with a cellphone and fill out an online questionnaire, which covers demographic and behavioral characteristics, and PrEP/PEP awareness and uptake. All participants provided online informed consent. The study protocol and informed consent form was approved by the institutional review board of National Center for AIDS/STD Control and Prevention. Results Between March and May 2019, the study enrolled 3,401 MSM. MSM being aware of, having consulted, and having taken PrEP and PEP accounted for 71.6%, 19.5%, 6.0%, 78.0%, 24.6%, and 11.4% respectively. Group sex and illicit drug use were associated with PrEP or PEP uptake. PrEP and PEP uptake was significantly associated with each other. MSM of 16-24 years old non-student were at higher risk of HIV infection and tested for HIV more frequently than other MSM, yet did not have higher PrEP/PEP uptake. Conclusions PrEP or PEP uptake was generally low among MSM in China. Integrating HIV testing, PrEP and PEP as an intervention package might facilitate PrEP/PEP uptake among the population. PrEP/PEP promotion should highlight MSM of 16-24 years old non-student.