The relationship between serum uric acid-creatinine ratio and risk factors of cerebral Hemodynamics and stroke in physical examination population

Abstract

Abstract Background The serum uric acid to creatinine ratio (SUA/Cr) is important in cardiovascular diseases. The aim of this study was to investigate the correlation between SUA/Cr ratio and cerebral hemodynamics and to analyze the relationship between different levels of SUA/Cr ratio and risk factors associated with stroke. Methods A population of 12,785 middle-aged and elderly medical checkups who completed CVHI testing at the First Affiliated Hospital of Xinjiang Medical University from June 2020 to May 2021 was selected for the study. The medical examination population was divided into Q1, Q2, Q3 and Q4 groups according to the quartiles of SUA/Cr ratio. The relationship between the SUA/Cr ratios and CVHI and stroke related risk factors in the middle-aged and elderly population was analyzed. Results A total of 12785 cases were included in the study, with an age range of 35 to 91 years and a mean of (50.64 ± 10.12) years. In the SUA/Cr grouping, the differences in the composition ratios of the population by gender and age were significant (P < 0.05), and the composition ratios of the population with abnormal systolic blood pressure, diastolic blood pressure, BMI, and history of alcohol consumption, hypertension, diabetes mellitus, and hyperlipidemia in the SUA/Cr grouping showed statistical significance (P < 0.05). the composition ratios of the group with abnormal blood pressure, alcohol consumption, history of hypertension, history of diabetes mellitus, and hyperlipidemia in the Q4 group were significantly higher than those of the other groups (P < 0.05), The composition ratios of the group with abnormal blood pressure, alcohol consumption, history of hypertension, history of diabetes mellitus, and history of hyperlipidemia were all significantly higher than those of the other groups (P < 0.05). As the ratio of SUA/Cr increases, the CVHI integral value will show a corresponding decreasing trend. Conclusions There is a correlation between SUA/Cr and CVHI, which should be given high priority.